A novel biomimetic polymer scaffold design enhances bone ingrowth
نویسندگان
چکیده
منابع مشابه
Hierarchically biomimetic bone scaffold materials: nano-HA/collagen/PLA composite.
A bone scaffold material (nano-HA/ collagen/PLA composite) was developed by biomimetic synthesis. It shows some features of natural bone both in main composition and hierarchical microstructure. Nano-hydroxyapatite and collagen assembled into mineralized fibril. The three-dimensional porous scaffold materials mimic the microstructure of cancellous bone. Cell culture and animal model tests showe...
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Rotator cuff tears represent the most common shoulder injuries in the United States. The debilitating effect of this degenerative condition coupled with the high incidence of failure associated with existing graft choices underscores the clinical need for alternative grafting solutions. The 2 critical design criteria for the ideal tendon graft would require the graft to not only exhibit physiol...
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BACKGROUND A novel, biodegradable, aliphatic polyurethane scaffold was designed to fulfill an unmet clinical need in the treatment of patients with irreparable partial meniscal lesions. HYPOTHESIS Treatment of irreparable partial meniscal lesions with an acellular polyurethane scaffold supports new tissue ingrowth. STUDY DESIGN Case series; Level of evidence, 4. METHODS Fifty-two patients...
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The bone ingrowth potential of biomimetic hydroxyapatite and brushite coatings applied on porous E-beam structure was examined in goats and compared to a similar uncoated porous structure and a conventional titanium plasma spray coating. Specimens were implanted in the iliac crest of goats for a period of 3 (4 goats) or 15 weeks (8 goats). Mechanical implant fixation generated by bone ingrowth ...
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Biomaterials with high osteogenic activity are desirable for sufficient healing of bone defects resulting from trauma, tumor, infection, and congenital abnormalities. Synthetic materials mimicking the structure and composition of human trabecular bone are of considerable potential in bone augmentation. In the present study, a zinc (Zn)-doped mesoporous hydroxyapatite microspheres (Zn-MHMs)/coll...
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ژورنال
عنوان ژورنال: Journal of Biomedical Materials Research Part A
سال: 2009
ISSN: 1549-3296,1552-4965
DOI: 10.1002/jbm.a.32251